The Role of Knowledge in Constructing the Quality of Olive Oil in Spain

The sustainability of a large proportion of Spanish olive oil-producing territories depends to a great extent on their capacity to fit into a specific model of food quality. The strategies used in the di erent territories di er with respect to their adherence to the objectifiable conception of quality, based on scientific-technical knowledge, or subjectivating conception of quality, based on tacit and practical knowledge. In this paper, we analyse the route taken by two territories with olive oil protected designation of origin (PDO) status in Spain to construct their quality model, the type of knowledge that has been applied and how knowledge processes a ect the construction of sustainable quality models. This study applies a qualitative methodology based on participative observation and semi-structured interviews with key actors of the territories. The results indicate that processes of production, reproduction and dissemination of knowledge are basic pillars for the construction of sustainable quality projects. The degree of understanding of the objectifiable and subjectivating conception of quality in olive-producing territories and the interaction between them depend on the specific characteristics of the territory, the objectives set in connection to the olive oil quality method, the importance given to the di erent types of knowledge, and its standing on the issue of territorial sustainabilit

Mitochondrial Genome Evolution, Genetic Diversity, and Population Structure in British Water Voles (Arvicola amphibius)

Funding: The research was supported by the Kent Mammal Group (KMG). Supplementary Materials: The following are available online at https://www.mdpi.com/2073-4425/12/2/138/s1, Table S1: Arvicolinae and outgroup mitochondrial genome accession numbers, Table S2: Sequenced Wildwood Trust water vole samples, Table S3: Additional water vole sequences from previous publications, Figure S1: ML phylogenetic tree of all available mtDNA genomes for Arvicolinae, Figure S2: ML phylogenetic tree of the 13 coding genes in the mitochondrial genome for Arvicolinae.Peer reviewedPublisher PD

Inverse problem for Lagrangian systems on Lie algebroids and applications to reduction by symmetries

The language of Lagrangian submanifolds is used to extend a geometric characterization of the inverse problem of the calculus of variations on tangent bundles to regular Lie algebroids. Since not all closed sections are locally exact on Lie algebroids, the Helmholtz conditions on Lie algebroids are necessary but not sufficient, so they give a weaker definition of the inverse problem. As an application the Helmholtz conditions on Atiyah algebroids are obtained so that the relationship between the inverse problem and the reduced inverse problem by symmetries can be described. Some examples and comparison with previous approaches in the literature are provided.Comment: Comments welcome

Drug Interactions With New Synthetic Opioids

Fentanyl, fentanyl analogs, and other new synthetic opioids (NSO) have burst onto the illegal drug market as new psychoactive substances (NPS). They are often sold as heroin to unsuspecting users and produce euphoria through their agonist action on μ- opioid receptors. Their high consumption, often combined with other substances, has led to multiple intoxications during recent years. In some countries, such as the United States, the consumption of opioids, whether for medical or recreational purposes, has become epidemic and is considered a public health problem. Fentanyl analogs are more potent than fentanyl which in turn is 50 times more potent than morphine. Furthermore, some fentanyl analogs have longer duration of action and therefore interactions with other substances and medicines can be more serious. This review is focused on the potentially most frequent interactions of opioid NPS taking into account the drugs present in the reported cases of poly-intoxication, including other illegal drugs of abuse and medication. Substances involved are mainly antidepressants, antihistamines, antipsychotics, benzodiazepines, analgesics, anesthetics, psychostimulants, other opioids, alcohol, and illegal drugs of abuse. The interactions can be produced due to pharmacokinetic and pharmacodynamic mechanisms. Naloxone can be used as an antidote, although required doses might be higher than for traditional opioid intoxications. It is crucial that doctors who habitually prescribe opioids, which are often misused by patients and NPS users, be aware of designer opioids' potentially life-threatening drug-drug interactions in order to prevent new cases of intoxication